Our program in Structural Biology and Biophysics focuses on the elucidation of structure-function relationships of key proteins and their complexes in the following five research domains.

We combine x-ray crystallography with biochemical and biophysical studies to understand the structural basis of hematopoietic receptor recognition and activation.

We focus on AggA, an outer-membrane type I secretion system protein from S. oneidensis.

1. Enzymatic glutathione biosynthesis is pivotal for redox balance in a cell. We combine structural biology with enzymology to study the bifunctional γ-glutamate-cysteine ligase-glutathione synthetase (GshF).

2. Dissection of the ligand specificity and mechanism of the Old Yellow Enzyme homologues from S. oneidensis at ultra-high resolution.

We pursue a number of nucleotide kinases and N-myristoyl transferase towards setting the stage for structure-based drug design.

We target several bacterial enzymes (e.g. disaccharide phosphorylases) to gain insights into fundamental protein structure-function principles and possible protein-engineering approaches towards  biotechnological application.